Matthew NicolettiAbout Matthew Nicoletti
Health systems financing leader, clinical research strategist and capital markets executive.
Perpetuals.com
Matthew Nicoletti joined the Board of Perpetuals.com Ltd (opens in a new tab) (Nasdaq: PDC) in January 2026 as an independent director and chair of the Compensation Committee, and was appointed Chief Strategy Officer and Director effective March 30, 2026. He leads corporate strategy for the company's regulated crypto derivatives infrastructure, the UpsideOnly platform and BayesShield AI, including BayesShield Clinical, announced in April 2026 to support diagnostic decision making in hospitals.
Health Finance and Research
As Senior Scientist of Health Finance at McMaster University, he works with faculty in the Department of Health Research Methods, Evidence, and Impact on research that translates clinical trial evidence into health policy, and has conducted financing evaluations across sub-Saharan Africa and Latin America. In 2026 he joined a McMaster and University of Global Health Equity collaboration on infectious disease surveillance across Central and East Africa.
He was lead funder and strategic partner of the TOGETHER Trial, an adaptive platform randomized trial in Brazil and Canada, and served on its Clinical Trial Committee. The trial received the 2021 David Sackett Clinical Trial of the Year Award from the Society for Clinical Trials. He also advises the Global Burden of Disease study at the Institute for Health Metrics and Evaluation, University of Washington.
Health Systems Financing, Republic of Rwanda
Primary Care Expansion & National Health Analytics Platform
- Co-designed and financed an $80 million blended funding mechanism (grants and loan instruments) that expanded Rwanda’s primary care clinic network from 350 to 620 facilities, a 77% increase in service delivery infrastructure.
- Enabled an estimated 1.2 million additional Rwandans to access primary care; reduced average travel time to facilities from approximately 47 to 24 minutes; supported growth in national health insurance coverage to over 80% of the population.
- Financed the Rwanda Health Analytics Platform, a national interoperability and analytics system integrating malaria, HIV, maternal and child health, and emerging infection data streams; the platform became central to Rwanda’s internationally recognized response to a Marburg virus outbreak.
ViRx@Stanford
He serves on the Advisory Board and as Senior Strategic Advisor to ViRx@Stanford (opens in a new tab), Stanford's biosecurity and pandemic preparedness initiative, advising on financing strategy for broad-spectrum antivirals and the BioShield platform.
Vadar Management
He founded Vadar Management LLC (opens in a new tab) in Florida in 2016, an advisory practice focused on M&A, capital markets and strategy for health sciences and technology companies. He is also founder of Distinguished LLC (RenovateFL), a Florida real estate development company.
Philanthropy
Together with spouse Laura Nicoletti, he committed more than $1.35 million to Orlando Health Arnold Palmer Hospital for Children, supporting advanced pediatric technologies and sustained care for mothers and children regardless of insurance status, as recognized by the Orlando Health Foundation (opens in a new tab).
Education
- Associate of Arts, Seminole State College
- Bachelor of Science, University of Central Florida
- MBA in Artificial Intelligence, University of East London
- PhD in Management candidate, European Institute of Management, Malta